Guarana, a native South American plant, contains guaranine, a substance chemically similar to caffeine with comparable stimulant effects. Guarana, Paullinia cupana, is often added to stimulant drinks either in combination with caffeine or on its own. The stimulant effect of guarana is related to its caffeine content; one gram of guarana contains as much caffeine, 40 mg, as a medium strength cup of coffee. The precise source and nature of the stimulant activity of guarana is not well understood. However, it has been reported that guarana exerts a more prolonged effect than an equivalent amount of caffeine, even though the stimulant action has been attributed to the presence of caffeine. In determining the overall caffeine content of a beverage, the guarana content must be taken into account along with the caffeine content.
In May 2001 the Food and Drug Administration, FDA, in the USA informed manufacturers of foods and drinks containing guarana and other herbal substances including echinacea and ginseng that the use of these herbs in food products was no longer permitted, forcing the withdrawal of a number of stimulant drink products from the US market. The US withdrawal of these products is based on US legislation that requires the manufacturers to prove that all ingredients are safe for use in foods, even if they have received prior approval for medical use. The impetus is now on the manufacturers of these products to produce scientific evidence to the FDA that these ingredients are safe. The Food Standards Agency in the UK has asked the European Commission to investigate the use of guarana and other herbs as stimulants and flavourings in stimulant drinks.